ZANTHINTM

PARRY'S NATURAL ASTAXANTHIN

The source of Parry’s Astaxanthin (ZanthinTM) is the world’s richest natural source Haematococcus Pluvialis, a green, fresh water algae that has commercial importance owing to its ability to accumulate Ketocarotenoid and Astaxanthin up to 2-3% (w/w) of dry weight.

The microalga Haematococcus pluvialis synthesizes and accumulates Astaxanthin to relatively high levels.

WHAT IS ASTAXANTHIN?

It’s an oxygen-containing carotenoid that belongs to the xanthophyll sub-group. Found commonly in most seafood like crab, shrimp, lobster, salmon, krill and algae.

Nowadays, a large proportion of commercial Astaxanthin is produced synthetically. This synthesis starts with a C-9 unit, ketoisophorone, which is obtained from petroleum feedstock

Astaxanthin in Haematococcus cells predominantly exists in 3S, 3'S form, which is biologically active. Astaxanthin gained applications in nutraceutical and pharmaceutical industries due to its greater antioxidant activity

Astaxanthin-graph
 Haematococcus

Haematococcus

NATURAL ASTAXANTHIN
THE SUPERIOR ANTIOXIDANT

Natural Astaxanthin in Haematococcus is predominantly present in the form of 3S, 3’S, which is very different from synthetic Astaxanthin, a petrochemical derivative where only ~25% is in the form of 3S, 3’S.

This natural form Astaxanthin of (3S, 3’S) is believed to be the major form that contributes to the human health benefits of Astaxanthin. Valensa International is the first company to have finished form Astaxanthin material approved for use by regulatory agencies in both the United States (NDI – New Dietary Ingredient) and Europe (Novel Foods).

Astaxanthin

THE MIRACLE ANTIOXIDANT

IS MUCH MORE THAN A SUPPLEMENT

Astaxanthin, a carotenoid belonging to the xanthophyll class has stirred great interest due to its antioxidant properties and its role in reducing the risk of some diseases. By belonging to the class of carotenoids called xanthophyll, Astaxanthin shares many of the metabolic and physiological activities attributed to carotenoids.

Key Characteristics

KEY Characteristics

  • Powerful Carotenoid Antioxidant
  • Soluble in Lipids, incorporates in cell membranes
  • Crosses the Blood-Retina & Blood-Brain Barriers
  • Singlet Oxygen Quenching
  • Free Radical Scavenging
  • Potent UVB Absorber
  • Reduces DNA Damage
  • Suppresses Inflammatory Markers

Astaxanthin is the most powerful lipophilic antioxidants yet discovered. As an antioxidant, it has been shown to be up to 500 times more powerful than Vitamin E, 10 times more potent as beta-carotene and 5 times more potent than lutein. This high level of antioxidant activity means much better ability to address the many age-onset conditions related to oxidative stress.

FREE RADICAL SCAVENGING

FREE RADICAL SCAVENGING

SINGLET OXYGEN QUENCHING

SINGLET OXYGEN QUENCHING

*The above claims are based on scientific literature.

ASTAXANTHIN IS UNLIKE ANY OTHER ANTIOXIDANT KNOWN BECAUSE OF ITS UNIQUE MOLECULAR STRUCTURE

  • It has polar (water-loving) end groups that can attach to the hydrophilic nodes on either side of the cell membrane, allowing it to span the cell's lipid bilayer.
  • Because of its long double-bonded chain, it can stabilize free radicals by adding them to its structure, rather than sacrificing an atom or electron
ASTAXANTHIN Structure

MEMBRANCE ALIGNMENT OF ASTAXANTHIN PREDICTS ACTIVITY

  • McNulty et al suggests that conformational differences in membrane alignment of antioxidants may help explain their biologic activity.
  • The antioxidant, anti-inflammatory activity of Astaxanthin depends on their precise trans-membrane alignment in the lipid bilayer of cellular membranes.
  • In addition to preventing lipid-based oxidation, this alignment provides a variation in the ability of the hydrophilic biophores in the end pieces to be adequately exposed to interact with reactive species in the aqueous environment, potentially facilitating ROS shuttling along the double bonds of the carbon backbone of the compound.

*The above claims are based on scientific literature.

Astaxanthin molecular structure

ANTI-INFLAMATORY HEALTH EFFECT

  • Besides being a strong unique antioxidant Astaxanthin also possess a powerful anti-inflammatory activity.
  • Astaxanthin’s anti-inflammatory properties are closely related to its potent antioxidant effects.
  • Astaxanthin inhibits signalling cascade of pro-inflammatory agents by suppressing NF-?B activation, as a result of scavenging intracellular ROS. The transcription factor NF-kB regulates the expression of many inflammatory genes including iNOS, COX-2,TNF?, and IL-1B , and aberrant activation of NF-?B is associated with a number of chronic inflammatory diseases.
  • Astaxanthin works on several different inflammatory pathways to suppress the production of inflammation causing agents in our bodies including TNF?, PGE2, Nitric oxide, Interleukin 1-B and COX 2 enzyme without exerting any negative effects to the body.

1.Astaxanthin absent in the cell.

  • 1A. The cell membrane is attacked by free radicals.
  • 1B. Activation of NF-kB.
  • 1C. Activation of genes involved in inflammation.

1.Astaxanthin present in the cell membrane.

  • 2A. Free radicals at the membrane are quenched.
  • 2B. Quenched free radicals cannot activate NF - kB
  • 2C. Inflammatory genes remain inactive.
Astaxanthin

*The above claims are based on scientific literature.

EFFECT ON HEALTH

  • ROS or reactive oxygen species are generated during any physical activity by the body and during rest, and are shown to have damaging effects on muscle performance and recovery.
  • Astaxanthin is known to prevent joint and muscle soreness after exercise.
  • In human trials Astaxanthin at 4mg/day completely prevented joint pain following strenuous exercise.
  • Astaxanthin protects the skeletal muscle from increased damage of oxidative stress generated by physical activity.
  • Astaxanthin increases the metabolism of lipids as the main source of energy production by protecting the carnitine palmitoyltransferase involved in fatty acid transport to the mitochondria.
  • The major causes of blindness are Age Related Macular Degenaration (ARMD) and Cataracts. The cellular damage is caused by free radicals and reactive oxygen species. Cataract is caused by lipid peroxidation of the epithelial layer of the lens.
  • Natural Astaxanthin is beneficial in alleviating the symptoms of ARMD / cataracts such as loss of vision, drusen formtion, blurred vision, loss of visual acuity, loss of dark vision, Scotoma, visual distortion (micorpsia and macropsia)
  • Prof. Mark Tso, University of Illinois, USA was the first to prove that Astaxanthin crossed the blood-brain-retina barrier and provided protection from photon-induced damage of photo-receptors, ganglion and neuronal cell damage.

*The above claims are based on scientific literature.

GROWN NEAR THE ANDES MOUNTAINS
FREE OF CONTAMINATION

Parry’s Astaxanthin (ZanthinTM) is manufactured at Chile, South America. This helps us grow the algae in a pristine and ideal environment enabling a high Astaxanthin content biomass without the possibility of contamination.

Our 44 hectare facility is located at an altitude of 400 meters above sea level, near the picturesque city of La Serena, with the Andes Mountains on one side and the Pacific Ocean on the other.

With an average temperature between 12 to 20 degree Celsius for most of the year and its low annual rainfall of 50 to 60 mm makes La Serena the most ideal location for growing a difficult species like Haematococcus. The Astaxanthin biomass produced from this site is considered to be the best quality achievable in the open pond cultivation method.

CULTIVATED IN CONTROLLED AND
SEMI-CONTROLLED ENVIRONMENTS

Haematococcus has two distinct phases in its life cycle, capable to grow under both photoautotrophic and heterotrophic conditions. Under favourable growth conditions, it exists as a single biflagellate, capable of autotrophic growth. During unfavourable growth conditions, Haematococcus initiates carotenogenesis and undergoes morphological transformation from green vegetative cells to deep red, Astaxanthin-rich, immotile aplanospores.

Parry produces natural Astaxanthin (ZanthinTM) from Haematococcus Pluvialis, grown in open raceway ponds that contain the growth medium along with the required amount of nutrients. On completion of Astaxanthin synthesis, the cells are harvested by filtration; adhering chemicals are removed by washing, the cell biomass is re-concentrated and then spray dried.

  • Cultivation

    Controlled indoor environment for green phase

  • Cultivation

    Semi controlled outdoor environment for red phase

  • Harvest

    By concentration

  • Cell Cracking and spray drying
  • Extraction
  • Final Product

ALL-NATURAL DEEP EXTRACT®

EXTRACTING THE HIGHEST AMOUNT OF ACTIVE INGREDIENTS

Parry employs a unique, proprietary two-part process using all-natural Deep Extract® (high pressure) supercritical CO2 to create the highest quality extraction. We also utilize our O2B® Peroxidation Blocker stabilization technology to ensure long-term stability and efficacy for the consumer. This process uses no co-solvents or ethoxyquin. This superior extraction method means that we obtain the highest amount of active ingredients.

Parry’s Astaxanthin (ZanthinTM) is extremely stable due to the O2B® package that we add
to our Astaxanthin products.

  • We guarantee a 4-year shelf life based on 7 years of excellent stability data on our product.
  • Our product is also produced in an allergen-free facility that is Organic Certified.
  • Valensa, subsidiary of EID Parry (India) Ltd is the only producer of Astaxanthin in the United States. All other competitors have their extraction done by third party off-shore contractors, some of whom also extract products such as green lipped mussels (shell fish) which contain serious allergens.
  • Valensa does not use Safflower oil, as a diluting agent, as one of our competitors does, because it introduces shelf life instability into the formulation. Valensa only uses extra virgin olive oil to standardize our Astaxanthin.
 

SAFETY - CONFORMING TO STRINGENT REGULATIONS

Safety specifications are as follows
  • Oral LD50

    :600 mg/kg (rats)

  • NOAEL

    :465 mg/kg (rats)

  • Serum Pharmacokinetics

    o T½ : 16 hrs.
    Tmax : 8 hrs.
    Cmax : 65 ?g/L

    : Stewart et al. 2008

  • 8 weeks of supplementation @ 6 mg/day

    :No negative effect in healthy adults. (Spiller et al. 2003)

valensa International

Valensa International, a subsidiary of Parry Nutraceuticals, is the first company to have a finished form of Astaxanthin approved for use by regulatory agencies in both the United States (NDI - New Dietary Ingredient) and Europe (Novel Foods).

PARRY'S ZANTHINTM

  • ZanthinTM is the only brand of Astaxanthin that is stabilized with a proprietary O2B™ Peroxidation blocker system
  • No other brand of Astaxanthin is stabilized with O2B technology
  • Novel Food approved
  • Highest stability of any Astaxanthin
  • Highest stability of any Astaxanthin
  • Solvent free, Non-GMO and extracted in an organic certified facility.